SPTAN1 抗体 (Cleaved-Asp1185)
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北京 101111
Quick Overview for SPTAN1 抗体 (Cleaved-Asp1185) (ABIN1536099)
抗原
See all SPTAN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1136-1185, Cleaved-Asp1185
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原理
- Cleaved-Spectrin α II (D1185) Antibody
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特异性
- Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
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别名
- SPTA2
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背景
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Synonyms: SPTAN1, NEAS, SPTA2, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit
Background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement.This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],
Gene Name: SPTAN1
Protein Name: Spectrin alpha chain non-erythrocytic 1
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分子量
- 137 kDa
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基因ID
- 6709
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OMIM
- 182810
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UniProt
- Q13813
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途径
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
抗原
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