GRM2 抗体 (AA 241-290)
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Quick Overview for GRM2 抗体 (AA 241-290) (ABIN1535755)
抗原
See all GRM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 241-290
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原理
- mGluR2 Antibody
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特异性
- MGluR2 Polyclonal Antibody detects endogenous levels of mGluR2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human GRM2. AA range:241-290
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亚型
- IgG
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应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))
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别名
- GRM2
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背景
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Synonyms: GRM2, GPRC1B, MGLUR2, Metabotropic glutamate receptor 2, mGluR2
Background: glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
Gene Name: GRM2
Protein Name: Metabotropic glutamate receptor 2
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分子量
- 95 kDa
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基因ID
- 2912
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OMIM
- 604099
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UniProt
- Q14416
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途径
- cAMP Metabolic Process, Dicarboxylic Acid Transport
抗原
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