GALR2 抗体 (AA 201-250)
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Quick Overview for GALR2 抗体 (AA 201-250) (ABIN1535690)
抗原
See all GALR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-250
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原理
- GALR2 Antibody
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特异性
- GALR2 Polyclonal Antibody detects endogenous levels of GALR2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human GALR2. AA range:201-250
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GALR2 (Galanin Receptor 2 (GALR2))
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别名
- GALR2
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背景
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Synonyms: GALR2, GALNR2, Galanin receptor type 2, GAL2-R, GALR-2
Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul
Gene Name: GALR2
Protein Name: Galanin receptor type 2
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分子量
- 41 kDa
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基因ID
- 8811
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OMIM
- 603691
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UniProt
- O43603
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途径
- cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour
抗原
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