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SESN1 抗体 (AA 271-320)

The 兔 多克隆 anti-SESN1 antibody is suitable to detect SESN1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA, IHC 和 IF.
产品编号 ABIN1535359
发货至: 中国
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Quick Overview for SESN1 抗体 (AA 271-320) (ABIN1535359)

抗原

See all SESN1 抗体
SESN1 (Sestrin 1 (SESN1))

适用

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人, 小鼠, 大鼠

宿主

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兔

克隆类型

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多克隆

标记

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This SESN1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

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    AA 271-320

    原理

    PA26 Antibody

    特异性

    PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    SESN1 (Sestrin 1 (SESN1))

    别名

    SESN1

    背景

    Synonyms: SESN1, PA26, SEST1, Sestrin-1, p53-regulated protein PA26

    Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

    Gene Name: SESN1

    Protein Name: Sestrin-1

    分子量

    56 kDa

    基因ID

    27244

    OMIM

    606103

    UniProt

    Q9Y6P5
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