RIN1 抗体 (AA 655-704)
Our Local Distributor
北京 101111
Quick Overview for RIN1 抗体 (AA 655-704) (ABIN1535259)
抗原
See all RIN1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 655-704
-
原理
- RIN1 Antibody
-
特异性
- RIN1 Polyclonal Antibody detects endogenous levels of RIN1 protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
纯度
- > 95 %
-
免疫原
- The antiserum was produced against synthesized peptide derived from human RIN1. AA range:655-704
-
亚型
- IgG
-
-
anti-Ras and Rab Interactor 1 (RIN1) (AA 1-783) antibody
RIN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (AA 1-783) antibodyRIN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (AA 20-70) antibodyRIN1 适用: 人 WB 宿主: 兔 Polyclonal RB46939 unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (C-Term) antibodyRIN1 适用: 人, 小鼠, 大鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (AA 192-341) antibodyRIN1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (AA 646-755) antibodyRIN1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ras and Rab Interactor 1 (RIN1) (AA 646-755) antibodyRIN1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated
-
-
应用备注
- WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- RIN1 (Ras and Rab Interactor 1 (RIN1))
-
别名
- RIN1
-
背景
-
Synonyms: RIN1, Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1
Background: function:Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.,PTM:Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylated on Ser-351 by PKD.,similarity:Belongs to the RIN (Ras interaction/interference) family.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 VPS9 domain.,subcellular location:Some amount is membrane-associated.,subunit:Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.,tissue specificity:Expressed in all tissues examined with high levels in brain, placenta and pancreas.,
Gene Name: RIN1
Protein Name: Ras and Rab interactor 1
-
分子量
- 84 kDa
-
基因ID
- 9610
-
OMIM
- 605965
-
UniProt
- Q13671
抗原
-
