Neurexin 1 抗体 (AA 502-551)
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北京 101111
Quick Overview for Neurexin 1 抗体 (AA 502-551) (ABIN1535088)
抗原
See all Neurexin 1 (NRXN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 502-551
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原理
- Neurexin I Antibody
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特异性
- Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551
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亚型
- IgG
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Neurexin 1 (NRXN1)
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别名
- NRXN1
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背景
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Synonyms: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alpha
Background: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
Gene Name: NRXN1
Protein Name: Neurexin-1-alpha
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分子量
- 161 kDa
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基因ID
- 9378
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OMIM
- 600565
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UniProt
- Q9ULB1
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途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
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