DPYSL4 抗体 (AA 91-140)
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北京 101111
Quick Overview for DPYSL4 抗体 (AA 91-140) (ABIN1534832)
抗原
See all DPYSL4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 91-140
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原理
- CRMP-3 Antibody
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特异性
- CRMP-3 Polyclonal Antibody detects endogenous levels of CRMP-3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))
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别名
- DPYSL4
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背景
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Synonyms: DPYSL4, CRMP3, ULIP4, Dihydropyrimidinase-related protein 4, DRP-4, Collapsin response mediator protein 3, CRMP-3, UNC33-like phosphoprotein 4, ULIP-4
Background: disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,
Gene Name: DPYSL4
Protein Name: Dihydropyrimidinase-related protein 4
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分子量
- 61 kDa
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基因ID
- 10570
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OMIM
- 608407
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UniProt
- O14531
抗原
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