Ataxin 2 抗体 (AA 731-780)
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北京 101111
Quick Overview for Ataxin 2 抗体 (AA 731-780) (ABIN1534657)
抗原
See all Ataxin 2 (ATXN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 731-780
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原理
- Ataxin-2 Antibody
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特异性
- Ataxin-2 Polyclonal Antibody detects endogenous levels of Ataxin-2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human ATXN2. AA range:731-780
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Ataxin 2 (ATXN2)
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别名
- ATXN2
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背景
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Synonyms: ATXN2, ATX2, SCA2, TNRC13, Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein
Background: ataxin 2(ATXN2) Homo sapiens This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA.The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The protein is primarily localized to the Golgi apparatus, with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization. In addition, the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegener
Gene Name: ATXN2
Protein Name: Ataxin-2
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分子量
- 140 kDa
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基因ID
- 6311
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OMIM
- 183090
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UniProt
- Q99700
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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