Apoptosis Inhibitor 5 抗体 (AA 421-470)
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Quick Overview for Apoptosis Inhibitor 5 抗体 (AA 421-470) (ABIN1534266)
抗原
See all Apoptosis Inhibitor 5 (API5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 421-470
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原理
- API5 Antibody
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特异性
- API5 Polyclonal Antibody detects endogenous levels of API5 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human API-5. AA range:421-470
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Apoptosis Inhibitor 5 (API5)
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别名
- API-5
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背景
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Synonyms: API5, MIG8, Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL
Background: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
Gene Name: API5
Protein Name: Apoptosis inhibitor 5
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分子量
- 57 kDa
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基因ID
- 8539
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OMIM
- 609774
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UniProt
- Q9BZZ5
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途径
- Growth Factor Binding
抗原
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