STRADA 抗体 (AA 11-60)
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Quick Overview for STRADA 抗体 (AA 11-60) (ABIN1533974)
抗原
See all STRADA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-60
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原理
- Strad Antibody
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特异性
- Strad Polyclonal Antibody detects endogenous levels of Strad protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- STRADA (STE20-Related Kinase Adaptor alpha (STRADA))
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别名
- STRAD
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背景
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Synonyms: STRADA; LYK5; STRAD; STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96
Background: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a ' pseudokinase' . The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009],
Gene Name: STRADA
Protein Name: STE20-related kinase adapter protein alpha
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分子量
- 48 kDa
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基因ID
- 92335
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OMIM
- 608626
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UniProt
- Q7RTN6
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途径
- AMPK Signaling
抗原
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