TNS3 抗体 (AA 541-590)
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北京 101111
Quick Overview for TNS3 抗体 (AA 541-590) (ABIN1533957)
抗原
See all TNS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 541-590
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原理
- Tensin3 Antibody
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特异性
- Tensin3 Polyclonal Antibody detects endogenous levels of Tensin3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590
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亚型
- IgG
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anti-Tensin 3 (TNS3) (AA 1-240) antibody
TNS3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tensin 3 (TNS3) (Center) antibodyTNS3 适用: 人, 大鼠 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tensin 3 (TNS3) (AA 1-301) antibodyTNS3 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- TNS3 (Tensin 3 (TNS3))
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背景
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Synonyms: TNS3, TEM6, TENS1, TPP, Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6
Background: function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.,induction:EGF induces down-regulation.,PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.,tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.,
Gene Name: TNS3
Protein Name: Tensin-3
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分子量
- 155 kDa
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基因ID
- 64759
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OMIM
- 606825
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UniProt
- Q68CZ2
抗原
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