COPS2 抗体 (AA 181-230)
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北京 101111
Quick Overview for COPS2 抗体 (AA 181-230) (ABIN1533798)
抗原
See all COPS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 181-230
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原理
- TRIP15 Antibody
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特异性
- TRIP15 Polyclonal Antibody detects endogenous levels of TRIP15 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human COPS2. AA range:181-230
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亚型
- IgG
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anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (AA 344-443) antibody
COPS2 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 4B12 unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (C-Term) antibodyCOPS2 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (C-Term) antibodyVerified COPS2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (AA 1-310) antibodyCOPS2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (N-Term) antibodyCOPS2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 猴, 马, 兔, 豚鼠, 小鸡, 非洲爪蟾, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (AA 1-310) antibodyCOPS2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) antibodyCOPS2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (N-Term) antibodyCOPS2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (AA 1-50) antibodyCOPS2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 小鸡, 非洲爪蟾 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) (N-Term) antibodyCOPS2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 猴, 马, 兔, 豚鼠, Drosophila melanogaster, 小鸡, 非洲爪蟾, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))
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别名
- COPS2
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背景
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Synonyms: COPS2, CSN2, TRIP15, COP9 signalosome complex subunit 2, SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15
Background: function:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.,PTM:Phosphorylated by CK2 and PKD kinases.,similarity:Belongs to the CSN2 family.,similarity:Contains 1 PCI domain.,subunit:Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1.,
Gene Name: COPS2
Protein Name: COP9 signalosome complex subunit 2
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分子量
- 51 kDa
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基因ID
- 9318
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OMIM
- 604508
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UniProt
- P61201
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途径
- Cell Division Cycle
抗原
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