MAP4K4 抗体 (AA 406-455)
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Quick Overview for MAP4K4 抗体 (AA 406-455) (ABIN1533570)
抗原
See all MAP4K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 406-455
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原理
- HGK Antibody
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特异性
- HGK Polyclonal Antibody detects endogenous levels of HGK protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human MEKKK 4. AA range:406-455
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
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别名
- MEKKK 4
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背景
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Synonyms: MAP4K4, HGK, KIAA0687, NIK, Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase
Background: mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) Homo sapiens The protein encoded byThis gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Gene Name: MAP4K4
Protein Name: Mitogen-activated protein kinase kinase kinase kinase 4
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分子量
- 142 kDa
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基因ID
- 9448
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OMIM
- 604666
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UniProt
- O95819
抗原
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