CLOCK 抗体 (AA 241-290)
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Quick Overview for CLOCK 抗体 (AA 241-290) (ABIN1533501)
抗原
See all CLOCK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 241-290
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原理
- Clock Antibody
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特异性
- Clock Polyclonal Antibody detects endogenous levels of Clock protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Clock. AA range:241-290
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- CLOCK (Clock Homolog (Mouse) (CLOCK))
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别名
- Clock
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背景
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Synonyms: CLOCK, BHLHE8, KIAA0334, Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8
Background: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Gene Name: CLOCK
Protein Name: Circadian locomoter output cycles protein kaput
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分子量
- 95 kDa
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基因ID
- 9575
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OMIM
- 601851
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UniProt
- O15516
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途径
- Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
抗原
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