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CLOCK 抗体 (AA 241-290)

This 兔 多克隆 antibody specifically detects CLOCK in WB, IHC, ELISA 和 IF. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN1533501
发货至: 中国
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Quick Overview for CLOCK 抗体 (AA 241-290) (ABIN1533501)

抗原

See all CLOCK 抗体
CLOCK (Clock Homolog (Mouse) (CLOCK))

适用

  • 71
  • 50
  • 43
  • 13
  • 3
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  • 3
  • 3
  • 2
  • 2
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  • 1
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  • 1
人, 小鼠, 大鼠

宿主

  • 66
  • 6
  • 1
  • 1
兔

克隆类型

  • 48
  • 26
多克隆

标记

  • 37
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  • 3
  • 3
  • 3
  • 3
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  • 2
  • 1
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This CLOCK antibody is un-conjugated

应用范围

  • 50
  • 30
  • 25
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  • 18
  • 4
  • 4
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • 抗原表位

    • 16
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 241-290

    原理

    Clock Antibody

    特异性

    Clock Polyclonal Antibody detects endogenous levels of Clock protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human Clock. AA range:241-290

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    CLOCK (Clock Homolog (Mouse) (CLOCK))

    别名

    Clock

    背景

    Synonyms: CLOCK, BHLHE8, KIAA0334, Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8

    Background: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

    Gene Name: CLOCK

    Protein Name: Circadian locomoter output cycles protein kaput

    分子量

    95 kDa

    基因ID

    9575

    OMIM

    601851

    UniProt

    O15516

    途径

    Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
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