NUB1 抗体 (AA 566-615)
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北京 101111
Quick Overview for NUB1 抗体 (AA 566-615) (ABIN1533431)
抗原
See all NUB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 566-615
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原理
- NUB1 Antibody
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特异性
- NUB1 Polyclonal Antibody detects endogenous levels of NUB1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))
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别名
- NYREN18
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背景
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Synonyms: NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18
Background: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events.The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici
Gene Name: NUB1
Protein Name: NEDD8 ultimate buster 1
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分子量
- 70 kDa
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基因ID
- 51667
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OMIM
- 607981
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UniProt
- Q9Y5A7
抗原
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