SIRPA 抗体 (AA 451-500)
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Quick Overview for SIRPA 抗体 (AA 451-500) (ABIN1533397)
抗原
See all SIRPA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 451-500
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原理
- SIRP-α1 Antibody
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特异性
- SIRP-α1 Polyclonal Antibody detects endogenous levels of SIRP-α1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Sirp alpha1. AA range:451-500
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
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别名
- Sirp Alpha1
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背景
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Synonyms: SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibito
Background: The protein encoded byThis gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati
Gene Name: SIRPA
Protein Name: Tyrosine-protein phosphatase non-receptor type substrate 1
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分子量
- 54 kDa
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基因ID
- 140885
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OMIM
- 602461
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UniProt
- P78324
抗原
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