Claudin 11 抗体 (AA 158-207)
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北京 101111
Quick Overview for Claudin 11 抗体 (AA 158-207) (ABIN1533234)
抗原
See all Claudin 11 (CLDN11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 158-207
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原理
- Claudin-11 Antibody
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特异性
- Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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: "Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS." in: PLoS ONE, Vol. 9, Issue 3, pp. e91372, (2014) (PubMed).
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- Claudin 11 (CLDN11)
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别名
- Claudin 11
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背景
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Synonyms: CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein
Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
Gene Name: CLDN11
Protein Name: Claudin-11
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分子量
- 21 kDa
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基因ID
- 5010
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OMIM
- 601326
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UniProt
- O75508
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途径
- Hepatitis C
抗原
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