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Claudin 11 抗体 (AA 158-207)

There is 1 publication for this product available. The 兔 多克隆 anti-Claudin 11 antibody is suitable to detect Claudin 11 in samples from 人, 小鼠 和 大鼠. It has been validated for WB 和 ELISA.
产品编号 ABIN1533234
发货至: 中国
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Quick Overview for Claudin 11 抗体 (AA 158-207) (ABIN1533234)

抗原

See all Claudin 11 (CLDN11) 抗体
Claudin 11 (CLDN11)

适用

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人, 小鼠, 大鼠

宿主

  • 65
兔

克隆类型

  • 53
  • 12
多克隆

标记

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This Claudin 11 antibody is un-conjugated

应用范围

  • 51
  • 22
  • 15
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  • 5
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Western Blotting (WB), ELISA
  • 抗原表位

    • 20
    • 15
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 158-207

    原理

    Claudin-11 Antibody

    特异性

    Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • Mogk, Meiwes, Shtopel, Schraermeyer, Lazarus, Kubata, Wolburg, Duszenko: "Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS." in: PLoS ONE, Vol. 9, Issue 3, pp. e91372, (2014) (PubMed).

  • 抗原

    Claudin 11 (CLDN11)

    别名

    Claudin 11

    背景

    Synonyms: CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein

    Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso

    Gene Name: CLDN11

    Protein Name: Claudin-11

    分子量

    21 kDa

    基因ID

    5010

    OMIM

    601326

    UniProt

    O75508

    途径

    Hepatitis C
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