PIN1 抗体 (AA 1-50)
Our Local Distributor
北京 101111
Quick Overview for PIN1 抗体 (AA 1-50) (ABIN1532476)
抗原
See all PIN1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-50
-
原理
- Pin1 Antibody
-
特异性
- Pin1 Polyclonal Antibody detects endogenous levels of Pin1 protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
纯度
- > 95 %
-
免疫原
- The antiserum was produced against synthesized peptide derived from human Pin1. AA range:1-50
-
亚型
- IgG
-
-
-
-
应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
-
别名
- Pin1
-
背景
-
Synonyms: PIN1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1
Background: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds.This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],
Gene Name: PIN1
Protein Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
-
分子量
- 18 kDa
-
基因ID
- 5300
-
OMIM
- 601052
-
UniProt
- Q13526
抗原
-