WWOX 抗体 (pTyr33)
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北京 101111
Quick Overview for WWOX 抗体 (pTyr33) (ABIN1532116)
抗原
See all WWOX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-67, pTyr33
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原理
- WWOX (phospho Tyr33) Antibody
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特异性
- Phospho-WWOX (Y33) Polyclonal Antibody detects endogenous levels of WWOX protein only when phosphorylated at Y33.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human WWOX around the phosphorylation site of Tyr33. AA range:18-67
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亚型
- IgG
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anti-WW Domain Containing Oxidoreductase (WWOX) (AA 1-180) antibody
WWOX 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 5-100) antibodyWWOX 适用: 人 WB, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 1-245) antibodyWWOX 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 1-245) antibodyWWOX 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 小鼠 Monoclonal 3D10 unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) antibodyKD Validated WWOX 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4780 unconjugated Recombinant Antibody
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 1-120) antibodyWWOX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (pTyr33) antibodyWWOX 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 1-189) antibodyWWOX 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) antibodyWWOX 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Oxidoreductase (WWOX) (AA 95-144) antibodyWWOX 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- WWOX (WW Domain Containing Oxidoreductase (WWOX))
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别名
- WWOX
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背景
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Synonyms: WWOX, FOR, WOX1, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase
Background: disease:Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239].,disease:Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.,domain:The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.,function:Probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with TP53/p53 to control genotoxic stress-induced cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death.,PTM:Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 2 WW domains.,subcellular location:Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Isoform 5 and isoform 6 may localize in the nucleus.,subunit:Interacts with TP53, TP73/p73 and MAPK8. Interacts with MAPT/TAU (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. May interact with COTE1/C1orf2 and SCOTIN.,tissue specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.,
Gene Name: WWOX
Protein Name: WW domain-containing oxidoreductase
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分子量
- 46 kDa
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基因ID
- 51741
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OMIM
- 133239
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UniProt
- Q96KM3
抗原
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