Aconitase 1 抗体 (pSer711)
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北京 101111
Quick Overview for Aconitase 1 抗体 (pSer711) (ABIN1531674)
抗原
See all Aconitase 1 (ACO1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 681-730, pSer711
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原理
- IRP-1 (phospho Ser711) Antibody
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特异性
- Phospho-IRP-1 (S711) Polyclonal Antibody detects endogenous levels of IRP-1 protein only when phosphorylated at S711.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human IREB1 around the phosphorylation site of Ser711. AA range:681-730
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亚型
- IgG
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anti-Aconitase 1 (ACO1) (AA 251-443) antibody
ACO1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 329-443) antibodyACO1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 26-243) antibodyACO1 适用: 人 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 508-745) antibodyACO1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 780-889) antibodyACO1 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Aconitase 1 (ACO1) (AA 1-889) antibodyACO1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (AA 1-137) antibodyACO1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) (N-Term) antibodyACO1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aconitase 1 (ACO1) antibodyACO1 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal AFfirm8481 unconjugated
anti-Aconitase 1 (ACO1) (N-Term) antibodyACO1 适用: 人, 大鼠, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Aconitase 1 (ACO1)
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别名
- IREB1
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背景
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Synonyms: ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1
Background: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct
Gene Name: ACO1
Protein Name: Cytoplasmic aconitate hydratase
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分子量
- 98 kDa
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基因ID
- 48
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OMIM
- 100880
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UniProt
- P21399
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途径
- Transition Metal Ion Homeostasis
抗原
-
