Phospholamban 抗体 (pSer16, pThr17)
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北京 101111
Quick Overview for Phospholamban 抗体 (pSer16, pThr17) (ABIN1531373)
抗原
See all Phospholamban (PLN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50, pSer16, pThr17
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原理
- PLB (phospho Ser16/T17) Antibody
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特异性
- Phospho-PLB (S16/T17) Polyclonal Antibody detects endogenous levels of PLB protein only when phosphorylated at S16/T17.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50
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亚型
- IgG
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anti-Phospholamban (PLN) (AA 1-52) antibody
PLN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-30) antibodyPLN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (pSer16) antibodyPLN 适用: 人 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (N-Term) antibodyVerified PLN 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-22), (N-Term) antibodyPLN 适用: 人 WB 宿主: 兔 Polyclonal RB44799 unconjugated
anti-Phospholamban (PLN) (pThr17) antibodyPLN 适用: 人, 大鼠 WB, DB 宿主: 兔 Polyclonal RB24137 unconjugated
anti-Phospholamban (PLN) (pSer16) antibodyPLN 适用: 人, 大鼠, 小鼠 IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (N-Term) antibodyPLN 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phospholamban (PLN) (AA 1-35) antibodyPLN 适用: 人 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Phospholamban (PLN)
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别名
- PLB
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背景
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Synonyms: PLN, PLB, Cardiac phospholamban, PLB
Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],
Gene Name: PLN
Protein Name: Cardiac phospholamban
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分子量
- 6 kDa
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基因ID
- 5350
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OMIM
- 172405
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UniProt
- P26678
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途径
- Negative Regulation of Transporter Activity
抗原
-
