KSR1 抗体 (pSer392)
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北京 101111
Quick Overview for KSR1 抗体 (pSer392) (ABIN1531231)
抗原
See all KSR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 358-407, pSer392
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原理
- Ksr-1 (phospho Ser392) Antibody
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特异性
- Phospho-Ksr-1 (S392) Polyclonal Antibody detects endogenous levels of Ksr-1 protein only when phosphorylated at S392.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human KSR around the phosphorylation site of Ser392. AA range:358-407
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亚型
- IgG
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anti-Kinase Suppressor of Ras 1 (KSR1) antibody
KD Validated KSR1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6290 unconjugated Recombinant Antibody
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 320-420) antibodyKSR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 404-598) antibodyKSR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 301-400) antibodyKSR1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 6C7 unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (pSer392) antibodyKSR1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 601-750) antibodyKSR1 适用: 人 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 1-30), (N-Term) antibodyKSR1 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3309 unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (Internal Region) antibodyKSR1 适用: 人, 小鼠, 大鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) antibodyKSR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (pSer392) antibodyKSR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- KSR1 (Kinase Suppressor of Ras 1 (KSR1))
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别名
- KSR
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背景
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Synonyms: KSR1, KSR, Kinase suppressor of Ras 1
Background: caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.,PTM:Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subcellular location:In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.,subunit:Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization.,
Gene Name: KSR1
Protein Name: Kinase suppressor of Ras 1
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分子量
- 102 kDa
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基因ID
- 8844
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OMIM
- 601132
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UniProt
- Q8IVT5
抗原
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