SOCS2 抗体 (AA 18-67)
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北京 101111
Quick Overview for SOCS2 抗体 (AA 18-67) (ABIN1453938)
抗原
See all SOCS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-67
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原理
- SOCS-2 Antibody
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特异性
- SOCS-2 Polyclonal Antibody detects endogenous levels of SOCS-2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human SOCS-2. AA range:18-67
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亚型
- IgG
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
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别名
- SOCS-2
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背景
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Synonyms: SOCS2, CIS2, SSI2, STATI2, Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2
Background: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor.The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has
Gene Name: SOCS2
Protein Name: Suppressor of cytokine signaling 2
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分子量
- 22 kDa
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基因ID
- 8835
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OMIM
- 605117
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UniProt
- O14508
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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