CRH 抗体 (AA 104-153)
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Quick Overview for CRH 抗体 (AA 104-153) (ABIN1453167)
抗原
See all CRH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 104-153
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原理
- CRF Antibody
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特异性
- CRF Polyclonal Antibody detects endogenous levels of CRF protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human CRF. AA range:104-153
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亚型
- IgG
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应用备注
- IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- CRH (Corticotropin Releasing Hormone (CRH))
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别名
- CRF
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背景
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Synonyms: CRH; Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
Background: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation a
Gene Name: CRH
Protein Name: Corticoliberin
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分子量
- 21 kDa
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基因ID
- 1392
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OMIM
- 122560
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UniProt
- P06850
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour
抗原
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