RHOB 抗体 (AA 99-148)
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北京 101111
Quick Overview for RHOB 抗体 (AA 99-148) (ABIN1451565)
抗原
See all RHOB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 99-148
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原理
- Rho B Antibody
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特异性
- Rho B Polyclonal Antibody detects endogenous levels of Rho B protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human RHOB. AA range:99-148
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亚型
- IgG
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anti-Ras Homolog Gene Family, Member B (RHOB) (AA 104-137) antibody
RHOB 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14498 unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) (C-Term) antibodyRHOB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) (C-Term) antibodyRHOB 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) (AA 107-156) antibodyRHOB 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, Pig, 绵羊, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) (AA 1-196) antibodyRHOB 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) antibodyRHOB 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) antibodyRHOB 适用: 人 DB 宿主: 小鼠 Monoclonal 2916C2a unconjugated
anti-Ras Homolog Gene Family, Member B (RHOB) (AA 1-196) antibodyRHOB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- RHOB (Ras Homolog Gene Family, Member B (RHOB))
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别名
- RHOB
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背景
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Synonyms: RHOB, ARH6, ARHB, Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6
Background: function:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.,miscellaneous:RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.,PTM:Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.,subunit:Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.,
Gene Name: RHOB
Protein Name: Rho-related GTP-binding protein RhoB
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分子量
- 22 kDa
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基因ID
- 388
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OMIM
- 165370
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UniProt
- P62745
抗原
-
