SIN3B 抗体 (AA 221-270)
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北京 101111
Quick Overview for SIN3B 抗体 (AA 221-270) (ABIN1450803)
抗原
See all SIN3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 221-270
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原理
- Sin3B Antibody
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特异性
- Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270
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亚型
- IgG
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应用备注
- WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))
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别名
- SIN3B
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背景
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Synonyms: SIN3B, KIAA0700, Paired amphipathic helix protein Sin3b, Histone deacetylase complex subunit Sin3b, Transcriptional corepressor Sin3b
Background: function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,
Gene Name: SIN3B
Protein Name: Paired amphipathic helix protein Sin3b
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分子量
- 133 kDa
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基因ID
- 23309
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OMIM
- 607777
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UniProt
- O75182
抗原
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