HCLS1 抗体 (pTyr397)
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北京 101111
Quick Overview for HCLS1 抗体 (pTyr397) (ABIN1450515)
抗原
See all HCLS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 366-415, pTyr397
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原理
- Lck BP-1 (phospho Tyr397) Antibody
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特异性
- Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human HS1 around the phosphorylation site of Tyr397. AA range:366-415
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亚型
- IgG
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anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibody
HCLS1 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibodyHCLS1 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2A9 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (N-Term) antibodyHCLS1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 161-260) antibodyHCLS1 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-356) antibodyHCLS1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 1-280) antibodyHCLS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 362-391), (C-Term) antibodyHCLS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34076 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (C-Term) antibodyHCLS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) antibodyHCLS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 28-77) antibodyHCLS1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
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别名
- HS1
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背景
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Synonyms: HCLS1, HS1, Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75
Background: developmental stage:Expressed in early stage of myeloid and erythroid differentiation.,function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN, rapidly after cross-linking of surface IgM on B-cells.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,
Gene Name: HCLS1
Protein Name: Hematopoietic lineage cell-specific protein
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分子量
- 53 kDa
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基因ID
- 3059
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OMIM
- 601306
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UniProt
- P14317
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location
抗原
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