ITGA4 抗体 (pSer1027)
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Quick Overview for ITGA4 抗体 (pSer1027) (ABIN1450329)
抗原
See all ITGA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 983-1032, pSer1027
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原理
- Integrin α4 (phospho Ser1027) Antibody
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特异性
- Phospho-Integrin α4 (S1027) Polyclonal Antibody detects endogenous levels of Integrin α4 protein only when phosphorylated at S1027.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human Integrin alpha4 around the phosphorylation site of Ser1027. AA range:983-1032
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亚型
- IgG
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应用备注
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ITGA4 (Integrin alpha 4 (ITGA4))
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别名
- Integrin Alpha4
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背景
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Synonyms: ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD antigen CD49d
Background: integrin subunit alpha 4(ITGA4) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Gene Name: ITGA4
Protein Name: Integrin alpha-4
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分子量
- 115 kDa
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基因ID
- 3676
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OMIM
- 192975
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UniProt
- P13612
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途径
- Integrin Complex
抗原
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