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Aggrecan 抗体

This anti-Aggrecan antibody is a 小鼠 单克隆 antibody detecting Aggrecan in WB, IP, IHC (p), IHC (fro) 和 EIA. Suitable for 人 和 Cow. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN1450192
发货至: 中国

Quick Overview for Aggrecan 抗体 (ABIN1450192)

抗原

See all Aggrecan (ACAN) 抗体
Aggrecan (ACAN)

适用

  • 89
  • 48
  • 34
  • 19
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
人, Cow

宿主

  • 91
  • 24
  • 1
  • 1
小鼠

克隆类型

  • 84
  • 33
单克隆

标记

  • 64
  • 15
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Aggrecan antibody is un-conjugated

应用范围

  • 86
  • 56
  • 37
  • 30
  • 23
  • 14
  • 14
  • 12
  • 8
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

克隆位点

HAG7D4 (7D4)
  • 交叉反应 (详细)

    Species reactivity (tested):Human and Bovine.

    纯化方法

    Prepared by Affinity Chromatography on Protein G from Tissue Culture Supernatant

    免疫原

    Purified Human articular cartilage Aggrecan. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the lyophilized product at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.
  • Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: "Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." in: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).

  • 抗原

    Aggrecan (ACAN)

    别名

    Aggrecan

    背景

    Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.Synonyms: ACAN, AGC1, CSPG1, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, MSK16

    基因ID

    176, 9606

    UniProt

    P16112

    途径

    Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport
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