Pellino 1 抗体 (C-Term)
Quick Overview for Pellino 1 抗体 (C-Term) (ABIN1450038)
抗原
See all Pellino 1 (PELI1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- A 15 amino acid peptide near the carboxy terminus of Human Pellino 1
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亚型
- IgG
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anti-Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) (AA 1-250) antibody
PELI1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) (C-Term) antibodyPELI1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) (AA 107-156) antibodyPELI1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) (AA 17-242) antibodyPELI1 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))
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别名
- PELI1
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背景
- The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-kB. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.Synonyms: PRISM, Pellino 1, Pellino-1, Pellino-related intracellular-signaling molecule, Protein pellino homolog 1
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分子量
- 46 kDa
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基因ID
- 57162
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NCBI登录号
- NP_065702
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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