BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).Synonyms: B-cell lymphoma 6 protein, BCL-5, BCL5, BCL6, LAZ-3, LAZ3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51