DBN1 抗体 (N-Term)
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Quick Overview for DBN1 抗体 (N-Term) (ABIN1449383)
抗原
See all DBN1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-326, N-Term
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交叉反应 (详细)
- Species reactivity (tested):Human.
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纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
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亚型
- IgG2b
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Tris buffered saline (TBS), pH ~8.0, 15 mM Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- DBN1 (Drebrin 1 (DBN1))
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别名
- Drebrin
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背景
- Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.Synonyms: D0S117E, DBN-1, DBN1, DKFZp434D064, Developmentally-regulated brain protein, drebrin 1
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基因ID
- 1627
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NCBI登录号
- NP_004386
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UniProt
- Q16643
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途径
- Maintenance of Protein Location
抗原
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