SCIMP 抗体
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北京 101111
Quick Overview for SCIMP 抗体 (ABIN1449307)
抗原
See all SCIMP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein-A affinity chromatography
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纯度
- > 95 % pure by SDS-PAGE
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免疫原
- Recombinant intracellular part of human SCIMP
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亚型
- IgG2a
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anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) antibody
SCIMP 适用: 人 IP, WB, ICC, ICFC 宿主: 小鼠 Monoclonal NVL-07 unconjugated
anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) antibody (PE)SCIMP 适用: 人 ICFC 宿主: 小鼠 Monoclonal NVL-07 PE
anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) (AA 59-145) antibodySCIMP 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
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别名
- SCIMP
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背景
- SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.Synonyms: SLP adaptor and Csk interacting membrane protein
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基因ID
- 388325
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NCBI登录号
- NP_996986
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UniProt
- Q6UWF3
抗原
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