EHMT2 抗体 (C-Term)
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Quick Overview for EHMT2 抗体 (C-Term) (ABIN1449182)
抗原
See all EHMT2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 621-1000, C-Term
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特异性
- This antibody reacts with both the 165 kDa G9a-L isoform and the 140 kDa G9a-S isoform.
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交叉反应 (详细)
- Species reactivity (tested):Human, Mouse
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纯化方法
- Protein A agarose
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免疫原
- GST-mouse G9a C-terminal protein (a.a. 621-1000)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))
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别名
- BAT8
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背景
- G9a (BAT8, NG36) is a major histone methyltransferase that acts by adding a methyl group to the Lys9 amino acid on histone H3 proteins. Methylation of Lys9 on histone H3 is important for the regulation of the expression of crucial genes during embryogenesis. Methylation of Lys9 may also play a role in tumorigenesis, since deregulation of histone H3 Lys9 methylation in G9a-deficient cells induces the expression of Mage-2a, a tumor-specific protein whose function is unknown. The 165 kDa G9a protein has an unusual structure, containing 24 contiguous glutamate residues in the N-terminus and 6 contiguous copies of a 33-amino acid ankyrin repeat in the C-terminus. The presence of the ankyrin repeats suggest that G9a may be involved in intracellular protein-protein interactions. G9a is expressed in monocytic, macrophage, hepatocyte, T-cell, B-cell, epithelial, and promyelocytic cell lines.Synonyms: C6orf30, EHMT2, Euchromatic histone-lysine N-methyltransferase 2, H3 lysine-9 specific 3, H3-K9-HMTase 3, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase, KMT1C, Lysine N-methyltransferase 1C, NG36, Protein G9A
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基因ID
- 110147
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NCBI登录号
- NP_665829
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UniProt
- Q9Z148
抗原
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