ES1 Protein Homolog (AA 1-281), (full length), (N-Term) 抗体
This 大鼠 单克隆 antibody specifically detects ES1 Protein Homolog in IF, IHC (p), IP 和 WB. It exhibits reactivity toward 大鼠.
产品编号 ABIN1449175
发货至:
中国
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Quick Overview for ES1 Protein Homolog (AA 1-281), (full length), (N-Term) 抗体 (ABIN1449175)
抗原
ES1 Protein Homolog
适用
大鼠
宿主
大鼠
克隆类型
单克隆
应用范围
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
克隆位点
NM1
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抗原表位
- AA 1-281, full length, N-Term
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特异性
- This antibody reacts with rat HES1.
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纯化方法
- Protein G agarose
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免疫原
- Full-length rat HES1 (1-281 aa)
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ES1 Protein Homolog
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背景
- Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I
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基因ID
- 294326
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NCBI登录号
- NP_001004225
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UniProt
- P56571
抗原
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