C18orf1 抗体 (PE-Cy7)
Quick Overview for C18orf1 抗体 (PE-Cy7) (ABIN1436981)
抗原
See all C18orf1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human C18orf1
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亚型
- IgG
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anti-Chromosome 18 Open Reading Frame 1 (C18orf1) (AA 1-306) antibody
C18orf1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 18 Open Reading Frame 1 (C18orf1) (AA 176-225) antibodyC18orf1 适用: 人, 小鼠, 大鼠, Cow, 马, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))
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别名
- C18orf1
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背景
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Synonyms: C18orf1, Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4
Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
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分子量
- 34kDa
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基因ID
- 753
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UniProt
- O15165
抗原
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