DSCAM 抗体 (PE)
Quick Overview for DSCAM 抗体 (PE) (ABIN1426575)
抗原
See all DSCAM 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Dscam
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亚型
- IgG
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应用备注
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FCM: 1:20-100
Optimal working dilution should be determined by the investigator. -
说明
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Exitation/Emission: 480,565nm/578nm
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at 4 °C
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有效期
- 12 months
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- DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))
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别名
- Dscam
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背景
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DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted.
Subcellular location: Extracellular
Synonyms: CHD2 42, CHD2 52, CHD2, Down syndrome cell adhesion molecule, DSCAM, DSCAM_HUMAN, human CHD2-52 down syndrome cell adhesion molecule 2, 9, OTTHUMP00000109193 2, SD11109p. -
途径
- Regulation of Cell Size
抗原
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