ZWILCH 抗体 (Cy3)
Quick Overview for ZWILCH 抗体 (Cy3) (ABIN1422209)
抗原
See all ZWILCH 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ZWILCH
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亚型
- IgG
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anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 1-477) antibody
ZWILCH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) antibodyZWILCH 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 1-477) antibodyZWILCH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C10 unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 482-508), (C-Term) antibodyZWILCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB38573 unconjugated
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应用备注
- IF(IHC-P) 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))
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别名
- ZWILCH
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背景
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Synonyms: hZwilch, KNTC1AP, MGC111034, Protein zwilch homolog, ZWILC_HUMAN, zwilch,y ZWILCH protein, Zwilch, kinetochore associated, homolog.
Background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.
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基因ID
- 55055
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UniProt
- Q9H900
抗原
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