PCGF2 抗体 (AA 170-210) (Cy7)
Quick Overview for PCGF2 抗体 (AA 170-210) (Cy7) (ABIN1421876)
抗原
See all PCGF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 170-210
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MEL18
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亚型
- IgG
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anti-Polycomb Group Ring Finger 2 (PCGF2) (AA 236-294) antibody
PCGF2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D6 unconjugated
anti-Polycomb Group Ring Finger 2 (PCGF2) (AA 170-210) antibodyPCGF2 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Polycomb Group Ring Finger 2 (PCGF2) (C-Term) antibodyVerified PCGF2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Polycomb Group Ring Finger 2 (PCGF2) (AA 103-316) antibodyPCGF2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF(IHC-P) 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))
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别名
- MEL18
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背景
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Synonyms: MEL-18, RNF110, ZNF144, Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18
Background: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).
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基因ID
- 7703
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UniProt
- P35227
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途径
- Chromatin Binding
抗原
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