CNOT2 抗体 (HRP)
Quick Overview for CNOT2 抗体 (HRP) (ABIN1420270)
抗原
See all CNOT2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human CNOT2
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 441-540) antibody
CNOT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F1 unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (Ser101) antibodyCNOT2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 1-335) antibodyCNOT2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (pSer101) antibodyCNOT2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 441-540) antibodyCNOT2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 1-540) antibodyCNOT2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 112-161) antibodyCNOT2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 非洲爪蟾, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (AA 251-300) antibodyCNOT2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) antibodyCNOT2 适用: 人 DB 宿主: 小鼠 Monoclonal 2191C2a unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 2 (CNOT2) (Ser101) antibodyCNOT2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- CNOT2 (CCR4-NOT Transcription Complex, Subunit 2 (CNOT2))
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别名
- CNOT2
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背景
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Synonyms: CCR4 associated factor 2, CCR4 NOT transcription complex subunit 2, CCR4-associated factor 2, CCR4-NOT transcription complex subunit 2, CDC36, CNOT2, CNOT2_HUMAN, HSPC131, MSTP046, Negative regulator of transcription 2, NOT2 negative regulator of transcription 2 yeast homolog, NOT2, NOT2H.
Background: CNOT2 (CCR4-NOT transcription complex subunit 2) is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family and is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT2) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase (HDAC) inhibitor trichostatin A.
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基因ID
- 4848
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance
抗原
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