KRIT1 抗体 (AA 631-736) (HRP)
Quick Overview for KRIT1 抗体 (AA 631-736) (HRP) (ABIN1417516)
抗原
See all KRIT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 631-736
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human KRIT1
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亚型
- IgG
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anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 631-736) antibody
KRIT1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 471-585) antibodyKRIT1 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 1-736), (N-Term) antibodyKRIT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
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别名
- KRIT1
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背景
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Synonyms: CAM, CCM1, Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1
Background: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1, this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
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基因ID
- 889
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UniProt
- O00522
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途径
- Cell RedoxHomeostasis
抗原
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