ZFYVE27 抗体 (AA 341-411) (Cy7)
Quick Overview for ZFYVE27 抗体 (AA 341-411) (Cy7) (ABIN1411152)
抗原
See all ZFYVE27 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 341-411
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Dog,Cow,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human ZFYVE27
-
亚型
- IgG
-
-
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (C-Term) antibody
ZFYVE27 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 兔, Bat, 小鸡, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (AA 251-300) antibodyZFYVE27 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 兔, Bat, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (AA 166-411) antibodyZFYVE27 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (AA 217-411) antibodyZFYVE27 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (C-Term) antibodyZFYVE27 适用: 人, 大鼠, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 27 (ZFYVE27) (Middle Region) antibodyZFYVE27 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))
-
别名
- ZFYVE27
-
背景
-
Synonyms: Protrudin, RP11 459F3.2, SPG33, ZFY27_HUMAN, ZFYVE27, zinc finger FYVE domain containing 27, Zinc finger FYVE domain containing protein 27, Zinc finger FYVE domain-containing protein 27.
Background: Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.
-
基因ID
- 118813
-
UniProt
- Q5T4F4
-
途径
- Neurotrophin Signaling Pathway
抗原
-
