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ZFYVE27 抗体 (AA 341-411) (Cy7)

This anti-ZFYVE27 antibody is a 兔 多克隆 antibody detecting ZFYVE27 in WB, IF (cc) 和 IF (p). Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN1411152
发货至: 中国

Quick Overview for ZFYVE27 抗体 (AA 341-411) (Cy7) (ABIN1411152)

抗原

See all ZFYVE27 抗体
ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))

适用

  • 41
  • 28
  • 28
  • 8
  • 6
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
人, 大鼠, 小鼠

宿主

  • 41

克隆类型

  • 41
多克隆

标记

  • 17
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This ZFYVE27 antibody is conjugated to Cy7

应用范围

  • 35
  • 14
  • 12
  • 12
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 14
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 341-411

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Dog,Cow,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human ZFYVE27

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))

    别名

    ZFYVE27

    背景

    Synonyms: Protrudin, RP11 459F3.2, SPG33, ZFY27_HUMAN, ZFYVE27, zinc finger FYVE domain containing 27, Zinc finger FYVE domain containing protein 27, Zinc finger FYVE domain-containing protein 27.

    Background: Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.

    基因ID

    118813

    UniProt

    Q5T4F4

    途径

    Neurotrophin Signaling Pathway
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