MTMR2 抗体 (AA 371-450) (Cy5)
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北京 101111
Quick Overview for MTMR2 抗体 (AA 371-450) (Cy5) (ABIN1410898)
抗原
See all MTMR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 371-450
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Pig,Chicken,Rabbit,Zebrafish
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MTMR2
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亚型
- IgG
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anti-Myotubularin Related Protein 2 (MTMR2) (AA 5-100) antibody
MTMR2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (AA 1-173) antibodyMTMR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (AA 404-643) antibodyMTMR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (C-Term) antibodyKO Validated MTMR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MTMR2 (Myotubularin Related Protein 2 (MTMR2))
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别名
- MTMR2
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背景
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Synonyms: CMT4B, CMT4B1, KIAA1073, MTMR2, MTMR2_HUMAN, Myotubularin related protein 2, Myotubularin-related protein 2.
Background: Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
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途径
- Inositol Metabolic Process, Synaptic Membrane
抗原
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