PRND 抗体 (AA 51-120) (Cy7)
Quick Overview for PRND 抗体 (AA 51-120) (Cy7) (ABIN1410894)
抗原
See all PRND 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-120
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预测反应
- Human,Mouse,Rat,Cow,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Doppel
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亚型
- IgG
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anti-Prion Protein 2 (Dublet) (PRND) (AA 20-160) antibody
PRND 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prion Protein 2 (Dublet) (PRND) antibodyPRND 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- PRND (Prion Protein 2 (Dublet) (PRND))
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别名
- Doppel/DPL
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背景
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Synonyms: DPL, Dublet, MGC41841, Prion gene complex downstream, Prion like protein doppel, Prion protein 2 dublet, Prion protein 2, Prion-like protein doppel, PRND, PRND_HUMAN, PrPLP.
Background: Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25 % sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.
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途径
- Transition Metal Ion Homeostasis
抗原
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