FEZF1 抗体 (AA 199-280) (HRP)
Quick Overview for FEZF1 抗体 (AA 199-280) (HRP) (ABIN1409516)
抗原
See all FEZF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 199-280
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ZNF312B
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亚型
- IgG
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anti-FEZ Family Zinc Finger 1 (FEZF1) (C-Term) antibody
FEZF1 适用: 人, 豚鼠, 马, 大鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FEZ Family Zinc Finger 1 (FEZF1) (C-Term) antibodyFEZF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FEZ Family Zinc Finger 1 (FEZF1) (AA 1-115) antibodyFEZF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FEZ Family Zinc Finger 1 (FEZF1) (AA 402-451) antibodyFEZF1 适用: 人, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-FEZ Family Zinc Finger 1 (FEZF1) (AA 67-96) antibodyFEZF1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
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别名
- ZNF312B/FEZF1
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背景
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Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.
Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.
抗原
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