Unc5c 抗体 (AA 201-288) (HRP)
Quick Overview for Unc5c 抗体 (AA 201-288) (HRP) (ABIN1409486)
抗原
See all Unc5c 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-288
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human UNC5H3
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亚型
- IgG
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anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (AA 88-117), (N-Term) antibody
Unc5c 适用: 人 WB 宿主: 兔 Polyclonal RB41789 unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) antibodyUnc5c 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (Internal Region) antibodyVerified Unc5c 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (AA 188-217) antibodyUnc5c 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21275 unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) antibodyUnc5c 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (N-Term) antibodyUnc5c 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (AA 395-444) antibodyUnc5c 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (C-Term) antibodyUnc5c 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (AA 300-360) antibodyUnc5c 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog C (C. Elegans) (Unc5c) (Middle Region) antibodyUnc5c 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))
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别名
- UNC5H3/UNC5C
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背景
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Synonyms: Alternative nameshomolog of C. elegans transmembrane receptor Unc5, Netrin receptor UNC5C, Protein unc 5 homolog C, Unc 5 homolog 3, Unc 5 homolog C, Unc5 C.elegans homolog c, UNC5H3, UNC5C_HUMAN.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H3, also known as UNC5C, plays an important role in the development of spinal accessory motor neurons. It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells.
抗原
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