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CASK 抗体 (AA 651-750) (HRP)

The 兔 多克隆 anti-CASK antibody is suitable to detect CASK in samples from 大鼠. It has been validated for ELISA, IHC (p) 和 IHC (fro).
产品编号 ABIN1408574
发货至: 中国
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北京 101111
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Room 801-803
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Quick Overview for CASK 抗体 (AA 651-750) (HRP) (ABIN1408574)

抗原

See all CASK 抗体
CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

适用

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大鼠

宿主

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克隆类型

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多克隆

标记

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This CASK antibody is conjugated to HRP

应用范围

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 651-750

    交叉反应

    大鼠

    预测反应

    Human,Mouse,Cow,Sheep,Pig,Horse,Chicken,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human CASK

    亚型

    IgG
  • 应用备注

    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

    别名

    CASK

    背景

    Synonyms: CAGH39, Caki, Calcium/calmodulin dependent serine protein kinase, Calcium/calmodulin dependent serine protein kinase MAGUK family, Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase, Calcium/calmodulin-dependent serine protein kinase, CAMGUK, CAMGUK protein, CAMGUK, drosophila, homolog of antibody casK, CMG, CSKP_HUMAN, DXPri1, DXRib1, FGS4, hCASK, LIN 2, Lin 2 homolog, LIN2 antibody Lin2 homolog, MICPCH, MRXSNA, Pals3, Peripheral plasma membrane protein CASK, Protein lin-2 homolog, TNRC8, Trinucleotide repeat containing 8, Vertebtate LIN2 homolog.

    Background: The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumor suppression, and signaling. CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterized by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is expressed in rat brain where it binds to cell-surface proteins, such as neurexin and syndecan, and is thought to be involved in signaling at neuronal synapses. CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, which binds to a specific DNA sequence (the T-element), and induces the expression of specific genes, including Reelin. CASK displays a transcription regulation function, which appears crucial for cerebrocortical development.

    途径

    Synaptic Vesicle Exocytosis
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