MCPH1 抗体 (AA 11-110) (Cy3)
Quick Overview for MCPH1 抗体 (AA 11-110) (Cy3) (ABIN1407915)
抗原
See all MCPH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-110
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交叉反应
- 小鼠
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预测反应
- Human,Dog
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
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亚型
- IgG
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anti-Microcephalin 1 (MCPH1) (AA 536-835) antibody
MCPH1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (N-Term) antibodyMCPH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) antibodyMCPH1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (AA 399-487) antibodyMCPH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (AA 399-487) antibodyMCPH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6F5 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MCPH1 (Microcephalin 1 (MCPH1))
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别名
- Microcephalin 1/BRIT1
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背景
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Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.
Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.
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途径
- Stem Cell Maintenance
抗原
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