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ALAS2 抗体 (Biotin)

ALAS2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN1403179
发货至: 中国
  • 抗原 See all ALAS2 抗体
    ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))
    适用
    • 46
    • 35
    • 31
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 37
    • 9
    克隆类型
    • 36
    • 10
    多克隆
    标记
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
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    • 1
    This ALAS2 antibody is conjugated to Biotin
    应用范围
    • 34
    • 13
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human ALAS2/ALAS-E
    亚型
    IgG
    Top Product
    Discover our top product ALAS2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))
    别名
    ALAS-E (ALAS2 产品)
    别名
    anh1 antibody, asb antibody, xlsa antibody, ALAS-E antibody, ALASE antibody, ANH1 antibody, ASB antibody, XLDPP antibody, XLEPP antibody, XLSA antibody, alas-e antibody, cb1063 antibody, sau antibody, sauternes antibody, ALAS antibody, Alas-2 antibody, 5'-aminolevulinate synthase 2 antibody, aminolevulinate, delta-, synthase 2 antibody, aminolevulinic acid synthase 2, erythroid antibody, alas2 antibody, ALAS2 antibody, Alas2 antibody, alas2.L antibody
    背景

    Synonyms: 5-aminolevulinate synthase, erythroid-specic, mitochondrial, 5-aminolevulinic acid synthase, ALAS E, ALASE, ANH1, Delta aminolevulinate synthase, XLSA, 5 aminolevulinic acid synthase 2, 5-aminolevulinate synthase 2, 5-aminolevulinate synthase, 5-aminolevulinate synthase 2, Alas 2, ALAS, ALAS E, ALAS, erythroid, ALASE, Aminolevulinate, delta-, synthase 2, Aminolevulinic acid synthase 2, erythroid, ANH1, ASB, Delta ALA synthase 2, Delta ALA synthetase, Delta aminolevulinate synthase 2, Delta aminolevulinate synthase, Erythroid specic ALAS, FLJ93603, XLDPP, XLSA.

    Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

    基因ID
    212
    途径
    Transition Metal Ion Homeostasis
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