FBXO11 抗体 (AA 65-160) (AbBy Fluor® 488)
Quick Overview for FBXO11 抗体 (AA 65-160) (AbBy Fluor® 488) (ABIN1399288)
抗原
See all FBXO11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 65-160
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FBXO11
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亚型
- IgG
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anti-F-Box Protein 11 (FBXO11) (AA 744-843) antibody
FBXO11 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 65-160) antibodyFBXO11 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 744-844) antibodyFBXO11 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 1-843) antibodyFBXO11 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (Middle Region) antibodyFBXO11 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, 犬, 豚鼠, 兔 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (Internal Region) antibodyFBXO11 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 181-453) antibodyFBXO11 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 754-765) antibodyVerified FBXO11 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 726-775) antibodyFBXO11 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, 犬, 豚鼠, 兔, 非洲爪蟾, 小鸡, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (C-Term) antibodyFBXO11 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, 犬, 豚鼠, 兔, 非洲爪蟾, 小鸡, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FBXO11 (F-Box Protein 11 (FBXO11))
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别名
- FBXO11
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背景
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Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11
Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
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基因ID
- 80204
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UniProt
- Q86XK2
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途径
- Sensory Perception of Sound
抗原
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